Menu ENN Search

The “ComPAS” trial combined treatment model for acute malnutrition: study protocol for the economic evaluation

Research snapshot1

Acute malnutrition is currently divided into severe (SAM) and moderate (MAM), based on level of wasting. SAM and MAM currently have separate treatment protocols and products, managed by separate international agencies. For SAM, the dose of treatment is allocated by the child’s weight. A combined and simplified protocol for SAM and MAM, with a standardised dose of ready-to-use therapeutic food (RUTF), is being trialled for non-inferior recovery rates and may be more cost-effective than the current standard protocols for treating SAM and MAM.

This paper describes the protocol for the economic evaluation of the ComPAS trial, a cluster-randomised controlled, non-inferiority trial2 that took place between May 2017 and July 2018. It compared a novel combined protocol for treating uncomplicated acute malnutrition to the current standard protocol in children age 6 to 59 months in South Sudan and Kenya. This study will calculate the total economic costs of both protocols from a societal perspective, using accounting data, interviews and survey questionnaires. The incremental cost of implementing the combined protocol will be estimated and all costs and outcomes will be presented as a cost-consequence analysis. Incremental cost-effectiveness ratio will be calculated for primary and secondary outcome, if statistically significant.

The authors hypothesise that implementing the combined protocol will be cost-effective due to streamlined logistics at clinic level, reduced length of treatment (especially for MAM) and reduced dosages of RUTF. The findings of this economic evaluation will be important for policy-makers, especially given the hypothesised non-inferiority of the main health outcomes. The publication of this protocol aims to improve rigour of conduct and transparency of data collection and analysis. It is also intended to promote inclusion of economic evaluation in other nutrition intervention studies, especially for MAM, and improve comparability with other studies.

 

Read more...

Endnotes 

1Lelijveld N, Bailey J, Mayberry A et al. (2018). The “compass Trial” combined treatment model for acute malnutrition: study protocol for the economic evaluation. Trials (2018) 19:252 https://doi.org/10.1186/s13063-018-2594-7

2It is expected that health outcomes will not be statistically significantly different between the intervention and control arms of the study.

More like this

FEX: ComPAS trial in South Sudan and Kenya: Headline findings and experiences

View this article as a pdf Lisez cet article en français ici By Bethany Marron, Pamela Onyo, Eunice N Musyoki, Susan Were Adongo and Jeanette Bailey Bethany Marron is...

FEX: Relapse and post-discharge body composition of children treated for acute malnutrition using a simplified, combined protocol

View this article as a pdf Research snapshot1 Severe and moderate acute malnutrition (SAM and MAM) affect more than 50 million children worldwide. Despite gains in the...

FEX: Integrated protocol for severe and moderate acute malnutrition in Sierra Leone

Summary of research1 Location: Sierra Leone What we know: Impliementing separate protocols for MAM and SAM treatment can be administratively cumbersome in emergency...

FEX: OptiMA study in Burkina Faso: Emerging findings and additional insights

View this article as a pdf Lisez cet article en français ici By Kevin PQ Phelan Kevin PQ Phelan is Nutrition Advisor at ALIMA, the Alliance for International Medical...

FEX: Defining and treating “high-risk” moderate acute malnutrition using expanded admission criteria (Hi-MAM Study): A cluster-randomised controlled trial protocol

View this article as a pdf By Natasha Lelijveld, David Taylor Hendrixson, Claire Godbout, Alyssa Los, Jukka M Leppänen, Aminata Koroma and Mark Manary Natasha Lelijveld...

FEX: Modelling an alternative nutrition protocol generalisable to outpatient (MANGO) study

View this article as a pdf Upcoming research Action Against Hunger conducts operational research with academic partners to contribute to building the scientific and...

FEX: Community health worker-led treatment for uncomplicated wasting: insights from the RISE study

View this article as a pdf Lisez cet article en français ici By Bethany Marron on behalf of the RISE study consortium Bethany Marron is a nutrition advisor and former...

FEX: Combined protocol for SAM/MAM treatment: The ComPAS study

By Jeanette Bailey, Rachel Chase, Marko Kerac, André Briend, Mark Manary, Charles Opondo, Maureen Gallagher and Anna Kim Jeanette Bailey is the Project Director for...

FEX: Food aid for nutrition: A landscape review of current research and implications for future studies

View this article as a pdf Lisez cet article en français ici By Maria Wrabel, Kristine Caiafa, Beatrice Lorge Rogers and Patrick Webb All authors are affiliated with...

FEX: Management of severe acute malnutrition by community health workers: Early results of Action Against Hunger research

View this article as a pdf Lisez cet article en français ici By Pilar Charle-Cuellar, Noemi Lopez-Ejeda, Magloire Bunkembo, Abdias Ogobara Dougnon and Hassane Toukou...

FEX: Report on innovations in CMAM

By Anne Marie Kueter, Claudine Prudhon, Emily Keane and Megan Gayford The implementation of community-based management of acute malnutrition (CMAM) as the standard model of...

FEX: Previous Field Exchange content on continuum of acute malnutrition care

View this article as a pdf Content previously published in Field Exchange is also relevant to this issue's focus on continuity of care for acutely malnourished children. You...

en-net: Do we have "SAM Cure Rate" in health facilities running CMAM program

In a health facility where there is both SAM and MAM services (CMAM). Admitted SAM cases who reached to MAM criteria by anthropometric measurements, What are we going to...

FEX: Response to malnutrition treatment in low weight-for-age children: secondary analyses of ComPAS trial data

View this article as a pdf Research summary1 Location: Kenya and South Sudan What we know: Children who are concurrently wasted and stunted (WaSt) have a very high mortality...

FEX: Community health worker-led treatment for uncomplicated wasting: insights from the RISE study

This is a summary of a Field Exchange field article that was included in issue 64. The original article was authored by Bethany Marron on behalf of the RISE study...

FEX: Cost-efficiency of a simplified protocol for wasting treatment in Mali

View this article as a pdf Lisez cet article en français ici Derek Lee is a Best Use of Resources Advisor for Nutrition at International Rescue Committee...

FEX: Factors affecting decision-making on use of combined/simplified acute malnutrition protocols in Niger, north-east Nigeria, Somalia and South Sudan

View this article as a pdf Summary of research1 By Naoko Kozuki, Mamadou Seni, Amin Sirat, Omar Abdullahi, Mena Fundi Eso Adalbert, Marie Biotteau, Jeanette Bailey, Amelia...

FEX: Impact of reduced dose of ready-to-use therapeutic foods in children with uncomplicated severe acute malnutrition in Burkina Faso

View this article as a pdf Research snapshot1 A randomised non-inferiority trial was undertaken to investigate the efficacy of a reduced ready-to-use therapeutic food (RUTF)...

FEX: Editorial perspective on the continuum of care for children with acute malnutrition

View this article as a pdf Lisez cet article en français ici By Jeremy Shoham and Marie McGrath, Field Exchange Co-Editors Rationale for FEX special edition We are...

FEX: en-net update

By Tamsin Walters, en-net moderator Over the past three months, 37 questions have been posted on en-net, generating 59 responses. The forum areas for Prevention and management...

Close

Reference this page

The “ComPAS” trial combined treatment model for acute malnutrition: study protocol for the economic evaluation. Field Exchange 58, September 2018. p10. www.ennonline.net/fex/58/compastrial

(ENN_6083)

Close

Download to a citation manager

The below files can be imported into your preferred reference management tool, most tools will allow you to manually import the RIS file. Endnote may required a specific filter file to be used.